專任師資

陳青諭 博士
陳青諭 博士 職稱: 助理教授
學歷: 國立台灣大學化學系博士
專長: 結構生物學
信箱: chinyuchen33@gmail.com
chinyuchen@cc.ncu.edu.tw
分機: 65074, 65094

個人介紹

  1. 職 稱:助理教授
  2. 學 歷:
    1. Ph.D. (1999-2006)
      Department of Chemistry, National Taiwan University, Taipei, Taiwan
      Coadvisors: Dr. Andrew H. -J. Wang and Dr. Sunney I. Chan 
      Ph.D. thesis: Structural basis of DNA binding mechanism of the hyperthermophilic chromosomal protein Sac7d from Sulfolobus acidocaldarius (耐熱性蛋白質Sac7d和DNA錯合物之晶體結構解析以及其結合機制之探討)
    2. M. S. (1996-1999)
      Department of Chemistry, National Taiwan University, Taipei, Taiwan
      Advisor: Dr. Oliver Y. Su
      Master thesis:Spectral and electrochemical characterization of ruthenium porphyrins (釕紫質的光譜性質與電催化反應)
    3. B.S. (1992-1996)
      Department of Chemistry, National Tsing Hua University, Hsinchu, Taiwan
  3. 經 歷:
    1. 08/2011-present    Assistant Professor, Department of Life Sciences, National Central University
    2. 07/2009-07/2011   Distinguished Postdoctoral Scholar, Academia Sinica
    3. 07/2007-06/2009   Regular Postdoctoral Fellows, Institute of Chemistry, Academia Sinica (with Dr. Wei-Hau Chang)
      Research Experience: Mapping RNA exit channel on transcribing RNA Polymerase II by FRET analysis.
    4. 08/2006- 06/2007 Postdoctoral Fellows, Institute of Chemistry, Academia Sinica (with Dr. Wei-Hau Chang)
      Research Experience: To locate individual subunit in a TAP-tagged eukaryotic protein complex with nano-golds by cryo-EM.
    5. 01/2001-07/2006    Ph.D. student, Institute of Biological Chemistry, Academia Sinica (with Dr. Andrew H. -J. Wang, Distinguished Research Fellow and Vice President of Academia Sinica)
      Research Experience:
      (1) Probing the DNA kink structure induced by the hyperthermophilic chromosomal protein Sac7d using site-directed mutagenesis and X-ray crystallography;
      (2) The role of the water in the protein-DNA complex from high resolution X-ray crystallography.
    6. 07/1997-01/1999    Master student, Department of Chemistry, National Taiwan University (with Dr. Oliver Y. Su)
      Research Experience: Electrocatalytic oxidation of styrene by a high valent ruthenium porphyrin cation radical.
  4. 現 職: 2008-present 國立中央大學 生命科學研究所 助理教授
  5. 個人網頁: http://www.ncu.edu.tw/~cychen/
  6. 聯絡方式:(03)422-7151 (分機 65074)
  7. FAX:(03) 422-8482
  8. E-mail:chinyuchen@cc.ncu.edu.tw

授課

  1. 遺傳學
  2. 分析生物化學
  3. 結構生物學
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研究領域

Structural Biology, protein-DNA interaction and single molecule study

 

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論文發表

期刊

    1. Wei-Hau Chang*, Michael T.-K. Chiu, Chin-Yu Chen, Chi-Fu Yen, Yen-Cheng Lin, Yi-Ping Weng, Ji-Chau. Chang, Yi-Min Wu, Holland Cheng, Jianhua Fu, I-Ping Tu. “Zernike phase plate cryo-electron microscopy facilitates single particle analysis of unstained asymmetric protein complexes” Structure 2010, 18(1), 17-27. (SCI, impact factor: 5.397)
    2. Chin-Yu Chen, Chia-Chi Chang, Chi-Fu Yen, Michael T.-K. Chiu and Wei-Hau Chang*. “Mapping RNA exit channel on transcribing RNA Polymerase II by FRET analysis” Proc. Natl. Acad. Sci. U. S. A. 2009, 106(1), 127-132. (SCI, impact factor: 9.38)
    3. Chin-Yu Chen, Tzu-Ping Ko, Ting-Wan Lin, Chia-Cheng Chou, Chun-Jung Chen and Andrew H.-J. Wang*. “Probing the DNA kink structure induced by the hyperthermophilic chromosomal protein Sac7d” Nucleic Acids Res., 2005, 33(1), 430-438. (SCI, impact factor: 7.552)
    4. Lubomír Dostál, Chin-Yu Chen, Andrew H.-J. Wang and Heinz Welfle*. “Partial B-to-A DNA transition upon minor groove binding of protein Sac7d monitored by Raman spectroscopy” Biochemistry, 2004, 43(30), 9600-9609. (SCI, impact factor: 4.008)
    5. Tzu-Ping Ko, Hsing-Mao Chu, Chin-Yu Chen, Chia-Cheng Chou and Andrew H.-J. Wang*. “Structures of the hypethermophilic chromosomal protein Sac7d in complex with DNA decamers” Acta Crystallogr D Biol Crystallogr., 2004, 60, 1381-1387. (SCI, impact factor: 2.943)
    6. Chia-Cheng Chou, Ting-Wan Lin, Chin-Yu Chen and Andrew H.-J. Wang*. “Crystal structure of the hyperthermophilic archaeal DNA-binding protein Sso10b2 at a resolution of 1.85 Angstroms” J. Bacteriol., 2003, 185, 4066-4073. (SCI, impact factor: 3.636)
    7. Fang-Chung Chen, Jinn-Hsuan Ho, Chin-Yu Chen, Y. Oliver Su and Tong-Ing Ho*. “Electrogenerated chemiluminescence of sterically hindered porphyrins in aquous media” J. Electroanal. Chem., 2001, 499, 17-23. (SCI, impact factor: 2.484)
    8. Chin-Yu Chen, Ellen Cheng, Shu-Hua Cheng and Y. Oliver Su*. “Electrocatalytic oxidation of organic compounds by ruthenium porphyrin” Porphyrins, 2000, 9 (3, 4), 134-139.
    9. Chin-Yu Chen, Shu-Hua Cheng and Y. Oliver Su*. “Electrocatalytic oxidation of styrene by a high valent ruthenium porphyrin cation radical” J. Electroanal. Chem., 2000, 487, 51-56. (SCI, impact factor: 2.484)
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榮譽事項

  1. Academia Sinica Distinguished Postdoctoral Scholars (2009, held by Academia Sinica, 10% annually).
    (2009 ~ 2011年中央研究院博士後研究學者)
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實驗室成員

專任助理
蔡孟儒

博士班學生
阮越康
碩士班學生
黃正宏 陳奕勳


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