專任師資

孫維欣 博士
孫維欣 博士 職稱: 教授
學歷: 英國倫敦大學分子生物學博士
專長: 分子神經生物學,細胞生物學,痛覺訊息機制
信箱: weihsin@cc.ncu.edu.tw
分機: 65054, 65055

個人介紹

  1. 職 稱:教授
  2. 學 歷:
    1. Ph.D: 1995-1999, 英國倫敦大學分子生物學博士
    2. B.S.: 1988 -1992, 國立台灣大學農業化學系
  3. 經 歷:
    1. 2011-2016 : 國立中央大學 生命科學系 副教授
    2. 2003-2011/7 : 國立中央大學 生命科學系 助理教授
    3. 2001-2003 : 博士後 美國國家衛生院 精神健康所
    4. 1999-2001 : 博士後 美國國家衛生院 兒童健康與人類發展所
  4. 現 職:2016-present 國立中央大學 生命科學系教授
  5. 聯絡方式:(03)422-7151 (分機 65055)
  6. FAX:(03) 422-8482
  7. E-mail:weihsin@cc.ncu.edu.tw

授課

  1. 普通生物學
  2. 生物化學
  3. 細胞學
  4. 細胞分子生物學
  5. 神經生物學
  6. G蛋白耦合受體
  7. 比較基因體學
top

研究領域

Pain Neurobiology, Molecular Neurobiology, Signal Transduction, G-protein-coupled receptors, Drug Discovery

慢性疼痛若無有效紓解,將會嚴重影響個人生活品質及社會醫療成本。全球約有15億人口受慢性疼痛所苦,其中3-4.5%為神經病變痛。最大止痛藥市場仍為美國,但亞太市場在2007-2017快速成長。新止痛藥發展的方向主要為關節炎、癌症及神經病變痛,然目前治療藥物侷限於副作用大或療效短 (30-40% 神經病變痛病人對單ㄧ治療有50%止痛療效)。因之,瞭解慢性疼痛的分子機制且找到止痛藥標的基因,有助於新止痛藥的發展。

本實驗室的研究主要著重於:

(1)探討慢性疼痛的分子機制 : 以臨床疾病 (e.g. 類風濕關節炎、神經病變痛)及小鼠模式 (e.g. knockout, knockdown) 佐以動物行為測試及細胞分子、生理與藥理分析探討慢性疼痛的分子機制。

(2)搜尋具潛力的止痛藥物標的基因:探討臨床治療上極佳藥物標的物-G蛋白偶合受體 (e.g. 酸敏性 、 血清素 G 蛋白偶合受體) 參與急性轉換成慢性疼痛及鏡像疼痛的作用機制,藉以搜尋具潛力的止痛藥物標的基因。

(3)止痛藥開發:利用細胞與動物藥理測試進行藥物篩選,開發有效且具選擇性的止痛藥或治療方法,緩解持續性疼痛。

 

top

論文發表

PAPERS

  1. Madda R, Lin SC, *Sun WH, *Huang SL. (2018) Plasma proteomic analysis of systemic lupus erythematosus patients using liquid chromatography/tandem mass spectrometry with label-free quantification. Peer J 6:e4730 (MOST 106-2320-B-008-004-MY3)
  2. Madda R, Lin SC, *Sun WH, *Huang SL. (2018) Differential expressions of plasma proteins in systemic lupus erythematosus patients identified by proteomic analysis. Journal of Microbiology, Immunology and Infection (in press) (103CGH-NCU-A4)
  3. Su YS, Mei HR, Wang CH, *Sun WH. (2018) Peripheral 5-HT3 mediates mirror-image pain by a cross-talk with acid-sensing ion channel 3. Neuropharmacology 130: 92-104 (MOST 104-2320-B-008-001, MOST 106-2320-B-008-004-MY3)
  4. Su YS, Huang YF, Wong J, Lee CW, Hsieh WS, *Sun WH. (2018) G2A as a threshold regulator of inflammatory hyperalgesia modulates chronic hyperalgesia. J Mol Neurosci. 64: 39-50 (MOST105-2320-B-008-003)
  5. Hsieh WS, Kung CC, Huang SL, Lin SC and *Sun WH. (2017) TDAG8, TRPV1, and ASIC3 involved in establishing hyperalgesic priming in experimental rheumatoid arthritis. Scientific Reports 7:8870 (MOST104-2745-B-008-001; 103CGH-NCU-A4)
  6. Dai SP, Huang YH, Chang CJ, Huang YF, Hsieh WS, Tabata Y, Ishii S, and *Sun WH. (2017) TDAG8 involved in initiating inflammatory hyperalgesia and establishing hyperalgesic priming in mice. Scientific Reports 7, 41415 (MOST103-2321-B-008-001; MOST104-2321-B-008-001)
  7. Lin SH, Steinhoff M, Ikoma A, Chang YC, Cheng YR, Chandra Kopparaju R, Ishii S, *Sun WH, *Chen CC. (2017) Involvement of TRPV1 and TDAG8 in pruriception associated with noxious acidosis. J Invest Dermatol 137, 170-178 (MOST 104-2320-B-008-001) 
  8. Su YS, *Sun, WH. (2016) Commentary: Serotonin Receptor 2B Mediates Mechanical Hyperalgesia by Regulating Transient Receptor Potential Vanilloid 1. J Neurol Neuromed (2016) 1(6): 23-26.
  9. Huang YH, Su YS, Chang CJ, and *Sun, WH. (2016) Heteromerization of OGR1 and G2A enhance proton signaling. J Recept Signal Transduct Res 36:633-644. (NSC102-2321-B-008-001; MOST 103-2321-B-008-001)
  10. Lee CC, Chen CL, Liu FL, Chiou CY, Chen TC, Wu CC, Sun WH, Chang DM, and Huang HS. (2016) Development of 1-Amino-4-(phenylamino)anthraquinone-2-sulfonate Sodium Derivatives as a New Class of Inhibitors of RANKL-Induced OsteoclastogenesisDevelopment of 1-Amino-4-(phenylamino)anthraquinone-2-sulfonate Sodium Derivatives as a New Class of Inhibitors of RANKL-Induced Osteoclastogenesis. Arch. Pharm. Chem. Life Sci. 349(5):342-55.
  11. Su YS, Chiu YY, Lin SY, Chen CC and *Sun WH. (2016) Serotonin receptor 2B mediates mechanical hyperalgesia by regulating transient receptor potential vanilloid 1 in isolectin B4-negative neurons. J Mol Neurosci. 59:113-125 (NSC992320-B-008-001-MY3, NSC102-2321-B-008-001)
  12. Sun WH and Chen CC. (2016) Roles of Proton-Sensing Receptors in the Transition from Acute to Chronic Pain. J Dent Res 95: 135-42 (MOST103-2321-B-008-001)
  13. Huang WY, Dai SP, Chang YC, *Sun WH (2015) Acidosis Mediates the Switching of Gs-PKA and Gi-PKCε Dependence in Prolonged Hyperalgesia Induced by Inflammation PLoS One 10(5):e0125022 (NSC101-2321-B-008-001 and NSC102-2321-B-008-001)
  14. Lin SH, Sun WH, Chen CC (2014) Genetic exploration of the role of acid-sensing ion channels. Neuropharmocology 94:99-118
  15. Su YS, *Sun WH, Chen CC (2014) Molecular mechanism of inflammatory pain. World Journal of Anesthesiology 3:71-81
  16. Huang YH, Chang CY, Chen CC, Yang CD and *Sun WH (2013) Distinct expression of Mas1-related G-protein-coupled receptor B4 in dorsal root and trigeminal ganglia-implications for altered behaviors in acid-sensing ion channel 3-deficient mice. J Mol Neurosci 51, 820-834 (NSC 101-2321-B-008-001, NCU-LSH-101-A-002)
  17. Wu WL, Cheng CF, Sun WH, Wong CW, Chen CC (2012) Targeting ASIC3 for pain, anxiety, and insulin resistance. Pharmacol & Therapeut 134, 127-138
  18. Lin SY, Chang WJ, Lin CS, Huang CY, Wang HF and *Sun WH. (2011) Serotonin receptor 5-HT2B mediates serotonin-induced mechanical hyperalgesia. J Neuorsci.(in press) (NSC 95-2311-B-008-004 and NSC 99-2320-B-008-001-MY3)
  19. Chen YJ, Huang CW, Lin CS, Chang WH, *Sun WH (2009) Expression and function of proton-sensing G-protein-coupled receptors in inflammatory pain. Molecular Pain 5, 39. (*corresponding authors)
  20. Huang, CW, Tzeng, JN, Chen, YJ, Tsai, WF, Chen, CC, and *Sun, WH. (2007) Nociceptors of dorsal root ganglion express proton-sensing G protein-coupled receptors. Mol. Cell. Neurosci. 36, 195-210. (*corresponding authors)
  21. Fang, Y.C., *Sun, W.H., Wu, L.C., Huang, H.D., Juan, H.F., and *Horng, J.T. (2006) RINGdb: An integrated database for G-protein-coupled receptors and regulators of G protein signaling. BMC genomics 7: 317 (*corresponding authors)
  22. Sun, W.H., and DePamphilis, M. (2004) Methods for detecting cells in S. phase. In Methods in Molecular Biology Vol 241 (Lieberman. H., ed.). Human Press Inc., Totowa, NJ. pp37~54.
  23. Chen, C.C., Zimmer. A., Sun, W.H., Hall, J., Brownstein, M.J., Zimmer, A. (2002) A role for ASIC3 in the modulation of high-intensity pain stimuli. PNAS 99, 8892-8897.
  24. Sun. W.H., and Coleman, T., and DePamphilis, M. (2002). Cell cycle-dependent regulation of the association between origin recognition proteins and somatic cell chromatin. EMBO J. 21, 1437-1446.
  25. Brooks, R.F. and Sun, W.H. (2001). Cell Prolif. 34, 162.
  26. Sun. W.H., Hola, M., Baldwin, N., Pedley, K., and Brooks, R.F. (2001). Heterogeneity in nuclear transport does not affect the timing of DNA synthesis in quiescent mammalian nuclei induced to replicate in Xenopus egg extracts. Cell prolif. 24, 55-67.
  27. Natale, D., Li, C.J., Sun, W.H., and DePamphilis, M. (2000). Selective instability of Orc1 protein accounts for the absence of functional origin recognition complexes during the M to G1 transition in mammals. EMBO J. 19, 2728-2738.
  28. Sun, W.H., Hola, M., Pedley, K., Tada, S., Blow, J.J., Todorov, I.T., Kearsey. S.E., and Brooks, R.F. (2000) The replication capacity of intact mammalian nuclei in Xenolus egg extracts declines with quiescence, but the residual DNA synthesis is independent of Xenopus MCM proteins. Hournal of Cell Science. 113, 683-695.
  29. Longothetou-Rella, H., Sun, W.H., and Brooks, R.F. (2000). Induction of DNA synthesis or apoptosis in mammalian nuclei by Xenopus egg extracts unable to support the replication of sperm chromatin. Cell Biology International. 24, 129-134.

     

Book Chapters

  1. Sun, WH and Dai SP (2018) Tackling pain associated with rheumatoid arthritis. In Advances in Pain Research: Mechanisms and Modulation of Chronic Pain. Ed by Shyu BC. Springer Publisher (in press)
  2. Sun, WH ,Su YS, Chen CC (2018) The transition from acute to chronic pain. In the Neurobiology of pain. Ed by Wood J. Oxford University press (in press)
  3. Sun, WH and Chen, CC. (2009) ASIC3 and proton-sensing G protein-coupled receptors. In Nociceptive and Neuropathic pain: mechanisms and treatments.  Ed. by Shyu B.C. and Chien CC. Research Signpost p33-52. (ISBN: 978-81-308-0368-5) (NSC93-2311-B-008-007)

Patents

  1. 孫維欣、黃雪莉、黃旭山 蒽醌[2,1-c][1,2,5]噻二唑-6,11-二酮化合物緩解疼痛的應用. Application no: 103108520; Application date: 2014/03/11 Taiwan patent is approved on 2016/3/30
  2. 孫維欣、黃雪莉、黃旭山 萘并[2,3-f] 喹喔啉-7,12-二酮化合物緩解疼痛的應用. Application no: 103108518; Application date: 2014/03/11 Taiwan patent is approved on 2016/3/16
  3. Sun WH, Huang SL, Huang HS. INDICATION OF NAPHTHO[2,3-F]QUINOXALINE-7,12-DIONE COMPOUND IN ALLEVIATING PAIN. USA patent No: US9284281, 2016/3/15
  4. Sun WH, Huang SL, Huang HS. (孫維欣、黃雪莉、黃旭山). INDICATION OF ANTHRA[2,1-c][1,2,5] THIADIAZOLE-6,11- DIONE COMPOUND IN ALLEVIATING PAIN (蒽醌[2,1-c][1,2,5]噻二唑-6,11-二酮化合物緩解疼痛的應用). USA patent No: US9192602 B2, 2015/11/2
  5. Huang SL, Lin SC, Sun WH.  (黃雪莉,林世昌,孫維欣). USE OF TUMOR NECROSIS FACTOR (TNF) RECEPTOR-ASSOCIATED FACTOR 7 (TRAF7) AS BIOMARKER FOR SYSTEMIC LUPUS ERYTHEMATOSUS (SLE), METHOD AND KIT FOR DETECTING OF HUMAN WITH SLE (腫瘤壞死因子受體相關因子7作為紅斑性狼瘡的生物標記物之用途、偵測人體患有紅斑性狼瘡的方法以及偵測人體患有紅斑性狼瘡的套組) Taiwan patent No: I 502199, 2015/10/1- 2033/5/22

 

top

榮譽事項

  1. 106學年度中央大學學術研究傑出獎
  2. 106學年度中央大學績優專利獎
  3. 104學年度教學優良獎
  4. 指導學生李岱穎獲得103年度大專生研究創作獎
  5. 102學年度優良導師獎
  6. 101年度年度中央大學理學院頂尖期刊論文獎
  7. 99年度中央大學理學院頂尖期刊論文獎
  8. 99學年度理學院優良教師獎
  9. 1995-1999, Overseas Research Students Awards, King's college London, U.K.
  10. 1990-1191, Book Coupon Awards, National Taiwan University, Taiwan.
top

學會會員

  1. 神經科學學會 The Society for Neuroscience, 2005- present
  2. 台灣中子學會 Taiwan Neutron Science Society (TWNSS), 2009-present
  3. 中華民國基礎神經科學學會 Neuroscience Society Taiwan 2011-present
top

實驗室成員

研究助理
謝瑋珊
博士班學生
蘇禹軒 龔家騏 吳同悟 戴士評
碩士班學生
黃真
陳芊樺 江澔 黃翊筑


== 畢業碩士班學生 ==

92 方昱慶 黃佳瑋黃淳瑩
93 陳映儒 張晉毓蔡維棻
94 林志信 曾健寧
96 蘇禹軒
97 張瑋仁
98 彭明隆 林詩媛 廖元邦
99 張雁晴
100 黃薇羽

 

實驗室合照照片

導生照片

 

top