網頁維護:蔡仁傑

更新日期:2021/01/27

研究成果

(Ma lab members in bold: graduate students#; postdocs†)

1. Thi Nguyen M#, Lin CH†, Liu SM#, Miyashita A, Ihn H, Lin H, Ng CH, Tsai JC#, Chen MH, Tsai MS, Lin IY#, Liu SC, Li LY, Fukushima S *, Lu J*, Ma N*, miR-524-5p reduces the progression of the BRAF inhibitor-resistant melanoma, Neoplasia, 2020, 22(12):789-799 (IF=5.696)
2. Chen CL, Yang SC, Lai CY, Wang CK, Chang CF, Lin CY, Chen WJ, Lin PY, Wu HC, Ma N, Lu FL, Lu J, CXCL14 Maintains hESC Self-Renewal through Binding to IGF-1R and Activation of the IGF-1R Pathway, Cells, 2020 Jul 16;9(7):1706. doi: 10.3390/cells9071706.
3. Chen CL#, Lin CH†, Li AL#, Huang CC, Shen BY, Chiang YU#, Fang PL#, Chang HC, Li, KL, Yang WC, Horng JT*, Ma N*,Plasma MicroRNA Profile is a Biomarker Associated with Urothelial Carcinoma in Chronic Hemodialysis Patients, Am J physiol Renal physiol, 2019,316(6):F1094-F1102 (IF=3.323, R/C=16/80 (Q1),Urology Nephrology)
4. Lin IY#, Chiou YS, Wu LC, Tsai CY, Chen CT, Chuang WC, Lee MC, Lin CC, Lin TT#, Chen SC, Pan MH*, Ma N*, CCM111 prevents hepatic fibrosis via cooperative inhibition of TGF-β, Wnt and STAT3 signaling pathways, Journal of Food And Drug Analysis, 2019, 27(1):184-194 (IF=4.176, R/C=13/135 (Q1), Food Science & Technology)
5. Li AL#, Chung TS, Chan YN#, Chen CL#, Lin SC, Chiang YU#, Lin CH†, Chen CC and Ma N*, microRNA expression pattern as an ancillary prognostic signature for radiotherapy, Journal of Translational medicine, 2018,16 (1): 341 (IF=4.098, R/C=41/136 (Q2), Medicine, Research & Experimental)
6. Liu SM#, Lin CH†, Lu J, Lin IY#, Tsai MS, Chen MH and Ma N*, miR-596 modulates melanoma growth by regulating cell survival and death, Journal of Investigative Dermatology, 2018, 138(4), 911-921 (IF=6.290, R/C=4/66 (Q1), Dermatology)
7. Chen WY, Ma N, Li TL, Su LJ, Chang YH, MicroRNA in situ hybridization with phosphate-methylated oligonucleotides (nDNA) probe, New Biotechology,2018, 44, S147 (IF=3.739, R/C= (Q1), Biotechology)
8. Lin IY#, Pan MH, Lai CS, Lin TT#, Chen CT, Chung TS, Chen CL, Lin CH†, Chuang WC, Lee MC, Lin CC, Ma N*, CCM111, the water extract of Antrodia cinnamomea, regulates immune-related activity through STAT3 and NF-κB pathways, Scientific Reports, 2017, 7(1):4862. (IF=4.122, R/C=12/64 (Q1), Multidisciplinary Sciences)
9. Hsu C-L, Chung F-H, Chen C-H, Hsu T-T, Liu S-M#, Chung D-S, Hsu Y-F, Chen C-L#, Ma N*and Lee H-C*, Genotypes of cancer stem cells characterized by epithelial-to-mesenchymal transition and proliferation related functions, (* Co-corresponding Author), Scientific Reports, 2016, 6:32523. (IF=4.259, R/C=10/64 (Q1), Multidisciplinary Sciences) 
10. Yen C-I, Liu SM#, Lo W-S , Wu J-W, Liu Y-H, Chein R-J, Yang R, Ma N*and Shieh F-K*, Cytotoxicity of Postmodified Zeolitic-Imidazolate Framework-90 (ZIF-90) Nanocrystals: Correlation between Functionality and Toxicity, (* Co-corresponding Author), Chemistry - A European Journal, 2016, 22(9):2925-9 (IF=5.317, R/C=29/166 (Q1),Chemistry, Multidisciplinary)
11. Lin S-J, Wu S-W, Chou Y-C, Lin J-H, Huang Y-C, Chen M-R, Ma N* and Tsai C-H*, Novel expression and regulation of TIMP-1 in Epstein Barr virus-infected cells and its impact on cell survival (* Co-corresponding Author), Virology 2015,481:24-3333 (IF=3.367, R/C=13/35 (Q2), Virology)
12. Wu C-C, Wu H-J, Wang C-H, Lin C-H, Hsu S-C, Chen Y-R, Hsiao M, Schuyler S C, Lu FL, Ma N, and Lu J, Akt suppresses DLK for maintaining self-renewal of mouse embryonic stem cells, Cell Cycle, 2015,14(8), 1207-1217 (IF=3.952, R/C=68/187, (Q2), Cell Biology)
13. Ma N*, Lai C-H#, Chung C-H, Yang J-M, Hsu K-Cheng, Chen C-Y, Chung T-S, Li S, Ho C-T, Pan M-H*, 5-Demethyl tangeretin is more potent than tangeretin in inhibiting dimethylbenz(a) anthracene (DMBA)12-O-tetradecanoyl phorbol-13-acetate (TPA)-induced skin tumorigenesis, (# Co-First Author), Journal of Functional Foods, 2014, 11:528-537
14. Liu SM#, Lu J, Lee, HC, Chung FH, and Ma N*, miR-524-5p suppresses growth of oncogenic BRAF melanoma by targeting BRAF and ERK2, Oncotarget, 2014, 5(19):9444-59
15. Lo W-S, Liu SM#, Wang S-C, Lin H-P, Ma N*, Huang H-Yand Shieh F-K*, A green and facile approach to obtain 100 nm zeolitic imidazolate framework-90 (ZIF-90) particles via leveraging viscosity effects (* Co-corresponding Author), RSC Advances, 2014, 4:52883-86
16. Lin CH, Wu JC, Chiou BH, Chen CH, Ma N, Chang CY, Tsen YK and Chen SC, MicroRNA regulation of DNA repair gene expression in 4-aminobiphenyl-treated HepG2 cells, Toxicology, 2014, 322:69-77 
17. Huang HN, Chen SY, Hwang SM, Yu CC, Su M-W, Mai W, Wang, HW, Cheng WC, Schuyler SC, Ma N, Lu FL, Lu J, miR-200c and GATA binding protein 4 regulate human embryonic stem cell renewal and differentiation, Stem Cell Research, 2014,12(2):338-353 
18. Chung, FH, Chiang, YR, Tseng, AL, Sung, YC, Lu, J, Huang, MC, Ma N*, Lee, HC*, Functional Module Connectivity Map (FMCM): A Framework for Searching Repurposed Drug Compounds for Systems Treatment of Cancer and an application to Colorectal Adenocarcinoma (* Co-corresponding Author), Plos One, 2014, 9(1): e86299. 
19. Chen Y-J, Thang M WC, Chan Y-T, Huang Y-F, Ma N, Yu AL, Wu C-Y, Hu M-L, Chiu K-P, Global assessment of Antrodia cinnamomea-induced microRNA alterations in hepatocarcinoma Cells, Plos One, 2013, 8(12): e82751. doi:10.1371 
20. Lee MF, Tsai ML, Chien LL, Cheng AC, Ma N, Ho CT, Pan MH, Phyto-Power dietary supplement potently inhibits dimethylnitrosamine-1 induced liver fibrosis in rats, Food & Function, 2013, 4(3):470-475
21. Wang CH#, Ma N*, Lin YT#, Wu CC, Hsiao M, Lu FL, Yu CC, Chen SY, Lu J. A shRNA functional screen reveals Nme6 and Nme7 are crucial for embryonic stem cell renewal. (# Co-First Author) Stem cells,2012, 30:2199–2211 
22. Chiou YS, Ma N, Sang S, Ho CT, Wang YJ, Pan MH, Peracetylated (-)-epigallocatechin-3-gallate (AcEGCG) potently suppresses dextran sulfate sodium-induced colitis and colon tumorigenesis in mice. Journal of Agricultural and Food Chemistry 2012, 60 (13), 3441-3451 
23. Mok JA, Kim PM, Lam HY, Piccirillo S, Zhou X, Jeschke G, Sheridan DL, Parker VD, Jwa M, Cameroni E, Niu H, Good M, Remenyi A, Ma NJ, et al. Deciphering protein kinase specificity through large-scale analysis of yeast phosphorylation site motifs. Science Signaling, 2010, 3(109):ra12 
24. Ma NJ and Stern DF. Regulation of the Rad53 Protein Kinase in Signal Amplification by Oligomer Assembly and Disassembly. Cell Cycle, 2008, 7(6): 808-817 
25. Ma JL, Lee SJ, Duong JK, and Stern DF. (2006). Activation of the Checkpoint Kinase Rad53 by the Phosphatidyl Inositol Kinase-like Kinase Mec1. J Biol Chem. 281(7):3954-63 (cited 48 times) (Note: Previous name: Ma Jia-Lin)
26. Shim EY#, Ma JL#, Oum, JH, Yanez Y, and Lee SE. (2005) The Yeast Chromatin Remodeler RSC Complex Facilitates End Joining Repair of DNA Double-Strand Breaks (# Co-First Author) Mol. Cell. Biol. 25: 3934-3944. (cited 166 times) (Note: previous name: Ma Jia-Lin)
27. Ma JL, Kim EM, Haber JE, and Lee SE. (2003) Yeast Mre11 and Rad1 Proteins Define a Ku-Independent Mechanism To Repair Double-Strand Breaks Lacking Overlapping End Sequences, Mol. Cell. Biol. 23: 8820-8828 (cited 301 times) (Note: Previous name: Ma Jia-Lin)
書目
Wang C-H, Ma N, Lin Y-T, Wu C-C, Wu H-J, Yu C-C, Hsiao M, Lu FL, Schuyler SC, and Lu J. Array-Based High Throughput Screen in Mouse Embryonic Stem Cells with shRNAs. Current Protocols in Stem Cell Biol. 2013, 26: 5C.3.1 - 5C.3.19. (Online ISBN: 9780470151808)
專利
1. Ma N, Chung TS, Chan YN, Chen CL, Lee AL, 預測癌症放射線治療之預後的分析器及方法Analyzer and method for predicting the prognosis of cancer after radiation therapy; US #15/691,730; Taiwan #106123853(approved); China #201710581670.0 (applying)
2. Ma N, Chen CL, Lin CH, Li AL, Huang, CC, ChangCH, 泌尿上皮癌的檢測套組及檢測方法 / Detection Kit And Detection Method For Urothelial Carcinoma, Taiwan, 107140464; US and China #201910126024.4 (applying)
3. Ma N, Huang, CC, Chang CH Chen CL, Li AL, 評估個體罹患泌尿上皮癌之風險的方法及其套組/ Method For Estimating A Risk For A Subject Suffering From Urothelial Carcinoma And Kit Thereof; Taiwan, 108103917, US and China (applying)
4. Ma N, Lin CH, Su HH, Chen CH, Glucose dehydrogenase and method for producing the dehydrogenase; US#62/192,074
技術移轉
1. 預測癌症放射線治療之預後的分析器及方法, 107/5/21-108/5/20, 見微生醫。
研討會文章
1. Thi Nguyen M, Lin CH, Liu SM, Miyashita A, Ihn H, Lin H, Ng CH, Tsai JC, Chen MH,Tsai MS, Lin IY, Liu SC, Li LY, Fukushima S *, Lu J*, Ma N*, miR-524-5p suppresses the progression of the BRAF inhibitor resistance in melanoma, The 27th Symposium on Recent Advances in Cellular and Molecular Biology, Pingtung, Taiwan. Feb. 5-7. 2020
2. Li AL, Chen CL, Chou CY, Lin CH, Lin SC, Chen CC, Huang CC, Ma N*, The microRNA classifiers as ancillary diagnosis biomarkers of urothelial carcinoma for chronic kidney disease. The 27th Symposium on Recent Advances in Cellular and Molecular Biology, Pingtung, Taiwan. Feb. 5-7. 2020
3. Huang CC and Ma N*, Identifying MiRNA Biomarkers for Diagnosis of Encapsulating Peritoneal Sclerosis, ASN Kidney Week 2019, Washington, DC USA, Nov.5-10, 2019 (Invited to be the short talk speaker)
4. Li AL, Chen CL, Chiang YR, Huang CC*, Ma N*, The microRNAs signature as ancillary diagnosis biomarker for urothelial carcinoma for chronic kidney disease patients, The 24th Taiwan Joint Cancer Conference, Taipei, May. 4-5,2019
5. Nguyen TMH, Lin CH, Liu SM, Tsai JC, Lin IY, Tsai MS, Chen MH, Ma N*, miR-524-5p blocks the progression of BRAF inhibitor-resistance melanoma cells through MAPK/ERK and PI3K/AKT signaling pathways, The 24th Taiwan Joint Cancer Conference, Taipei, May. 4-5,2019
6. Nguyen TMH, Lin CH, Liu SM, Tsai JC, Lin IY, Tsai MS, Chen MH, Ma N*, miR-524-5p blocks the progression of BRAF inhibitor-resistance melanoma cells through MAPK/ERK and PI3K/AKT signaling pathways, The 34th Joint Annual Conference of Biomedical Science, Taipei, Mar. 23-24,2019
7. Li AL, Zhong PR, Lin SY , Ma N*, The miRNAs in extracellular vesicles (EVs) involve in radiation induced bystander effects, The 34th Joint Annual Conference of Biomedical Science, Taipei, Mar. 23-24,2019
8. Fang PL, Li AL, Lin CH, Ma N*, Urothelial carcinoma related miRNAs regulate bladder cancer cell functions, The 34th Joint Annual Conference of Biomedical Science, Taipei, Mar. 23-24,2019
9. Lin CH, Chen CL, Li AL, Chiang YR, Huang CC, Ma N*, The microRNAs signature as ancillary diagnosis biomarker for urothelial carcinoma in dialysis patients, The 33th Joint Annual Conference of Biomedical Science, Taipei, Mar. 24-25,2018
10. Li AL, Chen CL, Chiang YR, Huang CC*, Ma N*, The microRNAs signature as ancillary diagnosis biomarker for urothelial carcinoma for chronic kidney disease patients, The 33th Joint Annual Conference of Biomedical Science, Taipei, Mar. 24-25,2018
11. Li AL, Chung TS, Chan YN, Chen CL, Chiang YU, Ma N*, The miRNA classifier as the ancillary prognostic biomarker for radiotherapy, Radiation Break-through: from DNA damage responses to precision cancer therapy, Oxford, UK, Mar. 12-14, 2018
12. Lin IY, Lin CH, Wei T, Tsai JC, Liu SM and Ma N*, Overexpression of miR-524 inhibits the growth of PLX4032-resistance melanoma through modulating MAPK/PI3K pathways, 2017 Biomedical Engineering Society Annual Symposium, Taoyuan, Nov. 17-18, 2017. (Oral presentation award)
13. Lin IY, Pan MH, Lai CS, Lin TT, Chen CT, Chung TS, Chen CL, Lin CH, Chuang WC, Lee MC, Lin CC and Ma N*, CCM111, the water extract of Antrodia cinnamomea, regulates immune-related activity through STAT3 and NF-κB pathways, 3rd Global Summit on Herbals & Traditional Medicine, Osaka, Oct. 18-20, 2017
14. Li AL, Chung TS, Chan YN, Chen CL, Chiang YU, Ma N*, Develop the microRNAs classifier as the ancillary prognosis for radiation therapy, The Society of Chinese Bioscientists in America (SCBA), Hangzhou, China, June 29-July3,2017
15. Ma N*, The effects and mechanisms of miR-524-5p and miR-596 in melanoma, BIT’s 10th Annual World Cancer Congress, Barcelona, Spain, May 19-21,2017 (Invited to be the speaker)
16. Chen CL, Li AL, Lin CH, Chiang YR, Chang HC, Yang WC, Ma N*,Exploration of MicroRNAs as New Potential Biomarkers for Urinary Tract Tumors in Chronic Dialysis Patients, ISN World Congress of Nephology, Mexico City, April 21-25, 2017
17. Tsai JC, Liu SM, Lin IY, Tsao W and Ma N*, miR-524-5p suppress the growth and migration in the PLX4032-resistance melanoma cells, The 32th Joint Annual Conference of Biomedical Science, Taipei, Mar. 25-26,2017
18. Li AL, Chan YN, Chang TS, Chen CL, Chiang YR, Wang SN, Ma N*. Develop microRNAs as the biomarkers for cancer radiation therapy. 2016 Annual meeting of the Taiwan Genomic Medicine and Biomarker Society Symposium on Clinical Application of Genomic Medicine, Kaohsiung, Taiwan. Nov. 19, 2016.
19. Lin CH, Wang SN, Tsai MS, Chen MN, Chen CL, Liu SM, Ma N* Detection of miR-524-5p expression by in situ hybridization as an ancillary biomarker in melanoma diagnosis. 2016 Annual Meeting of the Taiwan Genomic Medicine and Biomarker Society Symposium Clinical Application of Genomic Medicine, Kaohsiung, Taiwan, Nov. 19, 2016
20. Lin IY, Wu LC, Chung TS, Tsai CY, Chen CT, Lee MC, Chuang WC, Lin CC, Chen CL, Pan MH*, Ma N*. CCM111 improves chemical-induced liver fibrosis in rats. 15th Meeting of Consortium for Globalization of Chinese Medicine, Taipei, Taiwan, Aug. 22-26, 2016. (Invited to be the the panelist)
21. Tsai JC, Liu SM, Chang YP, Haung YC, Ma N*. miR-518f-5p attenuates proliferation and migration of melanoma cells The 31st Joint Annual Conference of Biomedical Science, Taipei, Taiwan, Mar. 26-27, 2016
22. Liu SM, Lin CH, Chen CT, Wang SN, Lin IY, Ma N*. miR-596 modulates melanoma growth through regulating cell survival and death. The 31st Joint Annual Conference of Biomedical Science, Taipei, Taiwan, Mar. 26-27, 2016
23. Wang SN, Lin CH, Tsai MS, Chen CL, Chen MH, Liu SM, Chan YN, Ma N*. The status of miR-524-5p and mitogen-activated protein kinase (MAPK) signaling pathway in melanoma patients. International Symposium and Workshop on The 31 th Joint Annual Conference of Biomedical Science, Taipei, Taiwan, March. 26-27, 2016
24. Lin IY, Wu LC, Tsai CY, Chen CT, Lee MC, Chuang WC, Lin CC, Chung TS, Chen CL, Pan MH*, Ma N*. CCM111 alleviates CCl4-induced liver fibrosis in rats. International Symposium and Workshop on Taiwan Medicinal mushrooms: Antrodia cinnamomea, Taipei, Taiwan, May. 6-8, 2016 (The poster paper Award)
25. Liu SM and Ma N*. miR-596 attenuates melanoma growth through regulating cell survival and apoptosis.  Cell symposia: Human Genomics, Singapore, Nov. 8-10, 2015 
26. Ma N, The effects of microRNAs in MAPK/ERK signaling pathway in melanoma, The 3rd EITA-Bio Conference, Taipei, Oct. 24-25, 2015(Invited to be the speaker)
27. Lin IY, Lai CS, Pan MH, Lin TT, Chen CT, Chen CL, Lin CH, Lee MC, Lin CC, Chuang WC, Chung TS, Ma N*, CCM111 regulates immune-related activity through STAT3 and NF-kB pathways, NHRI / IBMS Joint International Conference on Inflammation & Disease, Miaoli, Taiwan, Oct. 21-23, 2015 
28. Chiang YR, Lu J, Lee HC, Chen CL, Chung FH, Ma N*, The specificity of Tyloxapol in colorectal cancer cells, Hallmarks of Cancer: Asia, Beijing, China, 2014
29. Liu SM, Lu J, Lee, HC, Chung FH, and Ma N*, miR-524-5p suppresses growth melanoma by targeting BRAF and ERK2, Hallmarks of Cancer: Asia, Beijing, China, 2014 
30. Lin IY, Lai CS, Lin TT, Pan MH, Chen CT, Chuang WC, Lee MC, Lin CC, Ma N*, CCM111 regulates inflammation activity and affects immune-related signaling pathways, International Symposium and Workshop on Medical Mushroom: Antrodia cinnamomea, Taipei, 2014 (The poster paper Award)
31. Ma N*, The effects of microRNAs in MAPK signaling pathway, The 14th Frontier Science Symposium, Nanjing, China, 2013 (Invited to be the short talk speaker)
32. Wang SC, Liu SM, Ma N*, Shieh FK*. Alcohol-Based Synthesis of Nanoscaled Zeolitic Imidazolate Frameworks (ZIFs) and in vitro Toxicity Studies, 9th AFMC International Medicinal Chemistry Symposium, Taipei, 2013
33. Ma N, Chung CH, Chung TS, Li S, Ho CH, Pan MH*, Chemoprevention of azoxymethane-induced colonic tumorigenesis by oral administration of tangeretin and 5-demethyltangeretin, 9th AFMC International Medicinal Chemistry Symposium, Taipei, 2013
34. Chung FH, Chiang YR, Tseng AL, Ma N, Lu J, and Lee HC*, Functional Module Connectivity Map (FMCM): A Framework for Searching Repurposed Drug Compounds for Systems Treatment of Cancer and an application to Colorectal Adenocarcinoma, The 7th Asian Young Researchers Conference on Computational and Omics Biology, 2013, Tokyo Japan, 2013 September
35. Ma N, Jiang Z, Cheng YC*, YCC111 enhances anti-tumor activity of oxaliplatin, 5-fluorouracil (5-FU) and folinic Acid for colon tumors, 11th Meeting of Consortium for Globalization of Chinese Medicine, Macau, China, 2012 (Invited to be the short talk speaker)
36. Lin TT, Lai CS, Chiang YR, Pan MH, Chung, TS, Ma N*, CCM111 exhibits anti-inflammation activity through STAT3 signaling pathway, 11th Meeting of Consortium for Globalization of Chinese Medicine, Macau, China, 2012 (Invited to be the short talk speaker)
37. Wang CH, Ma N, Lin YT, Wu CC, Hsiao M, Lu FL, Yu CC, Chen SY, Lu J*. Nme 6 and Nme 7 is essential for mouse embryonic stem cell renewal. International Society for stem cell Research, 10th Annual Meeting, Yokohama, Japan, 2012
38. Wang CH, Ma N, Lin YT, Wu CC, Lin SJ, Tsai CH, Hsiao M, Lu F, Lu J*, A ShRNA Functional Screening of Kinase and Phophatase in ESC Renewal, International Society for stem cell Research, 9th Annual Meeting, Toronto, Canada, 2011